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Cluster Analysis of Rabies Virus-Host (Homosapiens) Network to Determine Various Viral Infections

Author(s): Y. Sai Sampath Kumar* and P. Jaya Simha Reddy*

Rabies is also known as Rhabdoviruses. It is a preventable viral disease transmitted through the bite of a rabid animal. It belongs to the family Rhabdoviridae order mononegavirals. Rabies infects the CNS of mammals, ultimately causing disease in the brain and death. Rhabdoviruse is approximately 180nm long, 70nm wide and 400 trimeric spikes which are tightly arranged on the surface of the virus. The genome encodes 5 proteins designated as nucleoprotein(N), phosphoprotein(P), matrix protein(M) ,glycoprotein(G) and a viral RNA polymerase protein(L). The clinical course of rabies occurs in five stages. Stage 1 is the incubation period, stage 2 is the prodromal period, stage 3 is the neurological period, stage 4 is coma stage 5 occurs infrequently is recovery. The current study determines the biological process of a virus against(Homosapiens). Here we retrieved an interaction network of rabies virus-host(homosapiens) from a string virus database. This network was further be analyzed and the resulted network was clustered. By performing gene ontology analysis for the clustered proteins we, therefore, identified proteins which has a highly effective role in cellular processes and viral infection mechanisms. Hence this study helps to understand the various proteins that can be targeted for further development in drug discovery and also in the prevention of this disease.


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