journal of biomedical informatics
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Chu-Ling Ko

Department of Computer Science, National Chiao Tung University, 1001 University Rd, Hsinchu, Taiwan

Publications

  • Original Article   
    Computational Ensemble Approach for Immune System Study: Conformational B-cell Epitope Prediction
    Author(s): Yuh-Jyh Hu*, Shun-Ning You and Chu-Ling Ko

    Various tools have been developed to predict B-cell epitopes. We proposed a multistrategy approach by integrating two ensemble learning techniques, namely bagging and meta-decision tree, with a threshold-based cost-sensitive method. By exploiting the synergy among multiple retrainable inductive learners, it directly learns a tree-like classification architecture from the data, and is not limited by a prespecified structure. In addition, we introduced a new three-dimensional sphere-based structural feature to improve the window-based linear features for increased residue description. We performed independent and cross-validation tests, and compared with previous ensemble meta-learners and state-of-the-art B-cell epitope prediction tools using bound-state and unboundstate antigens. The results demonstrated the superior performance of the bagging meta-decision tree approach compared with.. Read More»
    DOI: 10.24105/ejbi.2018.14.1.3