As nations around the world develop plans to achieve universal health coverage, assuring population coverage, service coverage, and financial protection calls for policies informed by evidence and the ability to implement such policies. The health systems around the world lack the necessary tools to accomplish these. The opportunity for redesigning healthcare systems and realigning the paradigm of healthcare delivery is provided by innovations and developing technologies, particularly digital health. Using information as a therapeutic tool in the context of redesigning health systems, novel models of care delivery, and contextualizing the recently released WHO Digital Health Guideline Recommendations for health systems strengthening enabler to achieve universal health coverage are just a few of the novel approaches described in this paper.