Introduction: Progressive health paradigms, involving many different disciplines and combining multiple policy domains, requires advanced interoperability solutions. This results in special challenges for modeling health systems.
Methods: The paper discusses classification systems for data models and enterprise business architectures and compares them with the ISO Reference Architecture.
Results and Conclusions: Existing definitions, specifications and standards for data models enabling interoperability are analyzed, and their limitations are evaluated. Amendments to correctly use those models and to better meet the aforementioned challenges are offered.