Most RNA handling happens co-transcriptionally. We cross examined early pol II records by compound and enzymatic testing, and decided how the “beginning RNA structureome” connects with joining, A-I altering and record speed. RNA collapsing inside introns and steep primary changes at graft destinations are related with proficient co-transcriptional joining. A sluggish pol II freak evokes broad redesigning into additional collapsed compliances with expanded A-I altering. Introns that become more organized at their 3’ graft destinations get co-transcriptionally extracted all the more productively. Slow pol II adjusted collapsing of intronic Alu components where secretive grafting and intron maintenance are invigorated, a result emulated by UV which decelerates record. Slow record additionally renovated RNA collapsing around elective exons in unmistakable ways that foresee whether skipping or consideration is leaned toward, despite the fact that it happens posttranscriptionally. Subsequently co-transcriptional RNA collapsing tweaks post-transcriptional elective joining. In rundown the versatility of early records widespreadly affects RNA handling.