Genetic interaction (GI) analysis may be a powerful genetic strategy that analyzes the fitness and phenotypes of single- and double-gene mutant cells so as to dissect the epistemic interactions between genes, reason genes into biological pathways, and characterize genes of unknown operate. Definition. In biological science, sequence-gene interaction (epistasis) is that the result of 1 sequence on a wellness changed by another gene or many alternative genes. Various kinds of epistemic sequence interaction area unit 1) Recessive epitasis (9:3:4) 2) Dominant hypostasis (12:3:1) 3) Dominant and recessive (inhibitory) hypostasis (13:3) 4) Duplicate recessive hypostasis (9:7) 5) Duplicate dominant hypostasis (15:1) and 6) chemical compound sequence interaction (9:6:1).