Infectious diseases are caused by bacteria, viruses, fungus, or parasites, which are microorganisms. These infections can cause epidemics or even pandemics if they are transmitted directly or indirectly. The infection that results might cause mild to severe symptoms like a life-threatening fever or diarrhoea. Infectious infections might be asymptomatic in some people but can have devastating consequences in others. Infectious infections remain a primary cause of death worldwide, particularly in low-income nations, despite medical improvements. Scientists may now better forecast epidemics, comprehend the specificity of each infection, and find possible therapeutic targets thanks to the development of clinical informatics tools. The goal of infectious disease informatics is to improve the clinical and public health management of infectious diseases through advances in antimicrobial development and use, vaccine design, biomarker discovery for life-threatening infections, a better understanding of host-pathogen interactions, and biosurveillance and clinical decision support.