Jana Zvárová had a lion's share in the founding of the Balneology Research Institute, a public research institute, in 2011. She played an important role in promoting the approach of Evidence Based Medicine and Information Based Medicine in the Czech balneology research. The aim was to establish a successor of the former state Balneological Research Institute, which was discontinued in 1992 without being replaced by another institution. Her scientific erudition has brought the elements of preclinical analysis and clinical evaluation into the scientific work of the Balneology Research Institute. The result was a scientific study not only of the extent of the positive effects but also of how natural remedies will improve the health state of the patient. In this contribution the project “The objective evaluation of the clinical effect of specifically selected natural remedies used for the treatment of knee osteoarthritis of the 2nd and 3rd degree” will be discussed as a tribute to Jana’s influence. The used methodology was a fundamental innovation in balneology science and research. Unfortunately this project wasn´t approved by The Ministry of Education, Youth and Sports support programs. We will follow Jana Zvárová’s approach in the future and will continue to try raising funds for the project.